Lenovo's existing ThinkPad Yoga hybrids have some power, but they're probably not your first choice for heavy-duty graphics work when they're saddled with integrated video. Thankfully, you now have a beefier option: Lenovo is introducing the ThinkPad P40 Yoga, its first 2-in-1 laptop with workstation-level 3D hardware. It still folds back into a tablet (or tent, or presentation mode), but its Quadro M500M chipset should be speedy enough to handle 3D modelling and other GPU-heavy tasks. You'll have greater control over those images, too, thanks to an included pen that promises both 2,048 levels of pressure and specially-tuned software that reportedly gets closer to the "pen to paper" feel.
You're looking at a fairly brawny machine in other respects. Every P40 Yoga ships with Quadro graphics as well as a 6th-generation Core i7 processor and a 512GB SSD; you can spec it up to 16GB of RAM, a 2,560 x 1,440 display and LTE data if you need more breathing room. It's a heavy slate at 3.9 pounds, but you probably won't mind unless you like to sketch while standing up. The biggest catch may simply be the wait -- the P40 Yoga won't ship until the first quarter of 2016, when it'll start at $1,399.
There are a couple of more conventional options launching around the same time. The $1,299 ThinkPad P50s is a lower-cost version of the regular P50 that ditches the Xeon chip for a Core i7, and maxes out with "just" a 2,880 x 1,620 display. And if you still need a desktop, the ThinkStation P310 starts at $729 and can carry up to a Xeon E3 processor, 64GB of RAM and various flavors of NVIDIA's pro graphics cards.