Latest in Science

Image credit: Henrik5000 via Getty Images

Scientists turn human kidney cells into tiny biocomputers

They found a way to program cells into following their instructions.
1913 Shares
Share
Tweet
Share
Save

Sponsored Links

Henrik5000 via Getty Images

A team of scientists from Boston University have found a way to hack into mammalian cells -- human cells, even -- and make them follow logical instructions like computers can. While they're not the first researchers to program cells to do their bidding, previous successful studies mostly used Escherichia coli, which are much easier to manipulate. These researchers were able to program human kidney cells into obeying 109 different sets of instructions, including responding to particular environmental conditions and following specific directions.

They were able to accomplish something other teams failed to do so by using DNA recombinases, genetic recombination enzymes that can recognize and stitch together two targets in a DNA strand and cut out anything in between. To trigger the recombinases, they inserted another gene in the same cells to start the cutting process.

Here's one sample of how it works: The researchers programmed cells to light up when they did NOT contain the DNA recombinase they used. In the future, they could use proteins associated with specific diseases to use technique as a diagnostic tool, since the samples would light up if the patient has the illness.

Wong says their current sets of instructions are just proofs of concept. Other potential applications include manipulating T cells into killing tumors by using proteins that can detect two to three cancer cell biomarkers. The technique could also be used to turn stem cells into any cells they want by using different signals, as well as to generate tissues on command. Wong and his team are only exploring those possibilities at the moment, though, and it'll take time before we see them happen.

All products recommended by Engadget are selected by our editorial team, independent of our parent company. Some of our stories include affiliate links. If you buy something through one of these links, we may earn an affiliate commission.
Comment
Comments
Share
1913 Shares
Share
Tweet
Share
Save

Popular on Engadget

Engadget's Guide to Privacy

Engadget's Guide to Privacy

View
FCC creates two 'innovation zones' to test next-gen wireless

FCC creates two 'innovation zones' to test next-gen wireless

View
‘Call of Duty’ comes to mobile on October 1st

‘Call of Duty’ comes to mobile on October 1st

View
AT&T reportedly considers offloading its DirecTV satellite unit

AT&T reportedly considers offloading its DirecTV satellite unit

View
T-Mobile’s Sprint merger is opposed by 18 state attorneys general

T-Mobile’s Sprint merger is opposed by 18 state attorneys general

View

From around the web

Page 1Page 1ear iconeye iconFill 23text filevr