For instance, I wish there were tanking fist weapons. I love, love, love fist weapons. I'd settle for a fist that had hit and expertise on it, even. But while I'm willing to switch to a slow main hander when I have a full rage bar to dump as Devastate threat (or for huge Cleaves when tanking lots of trash) it's just not really suitable for a good 80 to 90% of my time tanking. And yet, how I love fist weapons. I have an enhancement shaman, of course, and yet fists almost never drop for him (he's using axes at the moment) while they rain from the heavens and are almost constantly sharded when I'm tanking. I've taken to just picking them up and using them for fun. I understand there will most likely never be a dedicated tanking fist, as the only class that could use it would be a warrior (Paladins and DKs can't use fist weapons, Druids can but would almost never use one over a staff since they can't use shields).
Similarly, whenever I go elemental I always end up drooling over caster swords, and there have been a few times I've heard paladin healers sigh at a dagger drop. So what I turn to ask you is, what do you wish you could use? What drop can you either not equip or just can't effectively use?