Although both the show and the game will launch in April 2013, the game will kick things off in San Francisco, where players will meet the main characters of the show, Nolan and Arissa. Then the show will start after the two characters travel to St. Louis, Missouri. There, the series will unfold in the boom-town of Defiance while the game narrative continues in the Bay Area. Both the show and the game will influence each other and evolve together.
For more information on Defiance, check out its spotlight in The Firing Line and watch the Comic-Con videos.
[Source: Trion Worlds press release]