It seems there are two slowly diverging schools of thought in terms of working on a Mac: to multi-task, or not to. While an independent (though Apple-commissioned) study has been released supporting the increased productivity theory via larger displays and more stuff on-screen at once, not everyone sits in the same camp. Merlin Mann of 43folders is one of those campers who is thinking different, and Russell from our sister-blog DV Guru dropped a note to say the latest episode of MacBreak (iTS link) features Leo and Mr. Mann waxing ecstatic on all things uncluttered and distraction-free. They cover techniques and tweaks for clearing your workspace in the Finder, as well as using 3rd party tools like our TUAW-favorite Quicksilver, Spirited Away (which we've covered) and MenuShade from Nullriver Software (scroll down, it's under their Open Source section).
While I myself am firmly rooted in the 'more on screen = productivity' camp, I am a big fan of enabling users to work the way they need to, and I think this is a nice, quick video (it's only 4:20) to get started with the digital zen art of working clutter-free.