As a blogger here on TUAW I probably take an unusually high number of screenshots. I always have Grab and ImageWell running, so I can snag some pics of websites or of apps in action. That is, I always had Grab/ImageWell running, until I visited Plasq's booth on the Macworld showfloor.
Move over ImageWell: I have a new love, and its name is Skitch. Skitch is currently in a very private beta (we're talking single digit users at the moment), but the good folks at Plasq assure me that more info will be available next week. Skitch simplifies the way you take screenshots on your Mac. Think of it as a WYSIWYG screenshot taker (that's What You See Is What You Get) with the added bonus of making uploading those pics to a remote server (via FTP, SFTP, .Mac, or Flickr to name a few) dead simple. And it doesn't stop there; Skitch can also take pictures using your iSight and allows you to add text, doodles, and arrows to those images (and each of those elements is inserted onto its own layer, but Skitch handles all that... you need not interact directly with the layers).
Read on for a screenshot, though it really doesn't tell the whole story of this innovative UI.