Mysterious Dungeon: Shiren the Wanderer 3, whether it comes from enchanted weapons, scrolls, or -- for the first time -- talismans called o-fuda. While o-fuda are used in Shinto tradition to ward off harm from a home or family, their effects are a little more direct within the Mystery Dungeon. Shiren uses o-fuda to afflict status ailments on monsters.
Another advantage new to this entry: other characters. It's rare in a roguelike to have someone around who not only isn't a monster, but will in fact help you kill monsters. Not that any of this matters. Only the most dedicated, and luckiest, players will do anything in the game besides die. We have to keep telling ourselves that before we get sucked in to basically the hardest RPG on the Wii.