Grand Theft Auto IV is not appropriate for children. In a joint statement by the two organizations, the groups point out GTA IV has been rated Mature for: Intense Violence, Blood, Strong Language, Strong Sexual Content, Partial Nudity and Use of Drugs and Alcohol. What 12-year-old wouldn't beg to play that? It sounds awesome!
The two organizations "encourage parents to be informed and exercise their discretion when considering the purchase of all M-rated games." The ESRB reminds that the average age of a gamer is now over 30 and that some titles are "clearly not intended" for kids. And GTA IV is clearly one of those games.