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Scientists take a big step toward creating custom organisms
Scientists dream of using custom organisms to fight illnesses or even build computers, but there's a problem: it's difficult to make the sweeping genetic changes that would give you exactly the lifeform you need. To that end, researchers have found a way to rewrite "large stretches" of genomes with synthetic DNA. The team modified salmonella bacteria by using step-by-step recombineering (that is, exchanging sequences between similar pieces of DNA) to patch in yeast-grown genes that were "amplified" to boost their quality. The result was salmonella with 1,557 replacements spread across 176 genes -- a huge change for a relatively simple organism.
Researchers genetically engineer Salmonella to eat brain tumors
Salmonella has earned its bad reputation. It is responsible for more than a million cases of food poisoning every year, of which nearly 400 people die. But a team of researchers from Duke University have recently engineered the bacteria to not attack the human gastrointestinal tract, but rather the most aggressive form of brain cancer known to man.
Portable device can sniff out anthrax in an hour, won't bring the noise
Got some mysterious white powder sitting on your coffee table? A new, suitcase-sized device can tell you whether you've got dandruff, or anthrax. Developed by researchers at Cornell and the University of Albany, the detector uses a microfluidic chip (pictured on the left) to collect and purify the DNA on a given sample, before conducting a series of polymerase chain reactions -- processes that can quickly identify biological materials. The machine, which has been in the works for seven years, is powerful enough to deliver test results in just one hour (requiring a sample of only 40 microscopic spores), but is slim enough to fit in an airline's overhead luggage bin. Scientists say their creation could also be catered to pick up on other pathogens, including salmonella, and may even pay dividends for crime scene investigators handling forensic evidence. No word yet on when the device could hit the market, but we won't touch an ounce of sugar until it does.
