smallpox

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  • Smallpox lesions on skin are shown in this photograph taken in 1973  in Bangladesh. Smallpox infection was eliminated from the world in 1977. Smallpox is caused by variola virus with an incubation period of about 12 days following exposure. Initial symptoms include high fever, fatigue, and head and back aches. A characteristic rash, most prominent on the face, arms, and legs, follows in 2-3 days. The rash starts with flat red lesions that evolve at the same rate. Lesions become pus-filled and begin to crust early in the second week. Scabs develop and then separate and fall off after about 3-4 weeks. The majority of patients with smallpox recover, but death occurs in up to 30% of cases. Routine vaccination against smallpox ended in 1972.  
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    Hitting the Books: America might not exist if not for a pre-Revolution smallpox outbreak

    by 
    Andrew Tarantola
    Andrew Tarantola
    12.11.2022

    As historian Andrew Wehrman explains in The Contagion of Liberty: The Politics of Smallpox in the American Revolution that our downright violent resistance to, and demand for freedom from, this disease also helped galvanize our mobilization of independence from England.

  • Nurse Susan McCarthy gives the very first vaccine shot to Lino Fernandes, an Environmental Services Aide, at Backus Hospital where 211 doses of the Pfizer BioNTech Covid-19 vaccine were delivered and being given to 30 hospital workers on the first day of vaccinations in Norwich, Connecticut on December 15, 2020. (Photo by Joseph Prezioso / AFP) (Photo by JOSEPH PREZIOSO/AFP via Getty Images)

    How the world went from no COVID vaccines to two in under a year

    by 
    Andrew Tarantola
    Andrew Tarantola
    12.22.2020

    The next stage involves testing the vaccine on animals. By November, just four months after beginning phase III trials, the company demonstrated its vaccine to be 94 percent effective in preventing COVID infection.

  • Decade3d via Getty Images

    Scientists revive an extinct virus using off-the-shelf DNA

    by 
    Jon Fingas
    Jon Fingas
    07.09.2017

    It's no longer far-fetched to synthesize a basic organism. However, a team of researchers has taken that work one step further. They recently reconstituted and reanimated an extinct virus, horsepox, using DNA they'd ordered via mail. The team stitched together multiple gene fragments (each with about 30,000 base pairs) into the complete 212,000-pair horsepox genome and inserted it into cells already infected with a different pox, bringing the inanimate virus to life. It's clever work, especially given the relative complexity of a pox virus compared to earlier efforts, but it's also a double-edged sword -- it could at once provide a breakthrough in medical research and pose a potential threat.