Vaccine
Latest
Experimental Zika vaccine approved for human trials
The Food and Drug Administration approved an experimental Zika vaccine called GLS-5700 for a clinical trial in humans earlier today, the first such treatment to get an official nod from the agency. Initial trials will start with 40 healthy subjects getting dosed in the coming weeks, and if all goes without a hitch, preliminary results should be available later this year.
US military wants vaccines that adapt to fight new viruses
Vaccines and other antiviral treatments have one overriding, seemingly inescapable problem: since viruses evolve, a solution that works today can be completely useless tomorrow. The researchers at DARPA are convinced this is a solvable problem, however. They've launched an INTERCEPT (Interfering and Co-Evolving Prevention and Therapy) program that aims to create therapies which adapt in sync with the viruses they're meant to thwart. It'll largely revolve around therapeutic interfering particles (TIPs), or tiny slices of protein-shelled DNA that infiltrate cells and compete with viruses for protein shells. Since the particles should be produced faster than viruses, you end up with loads of dud viruses that dramatically reduce the impact of any viral load. Think of it as watering down a stiff drink.
Flu-fighting teenager takes home top prize at Google Science Fair 2013
Google Science Fair 2013 came to a close yesterday, as 15 young scientists aged between 13 and 18 demonstrated their projects in front of Google's expert panel. With over a thousand submissions worldwide, only four entrants were able to take home prizes, but it was 17-year-old Eric Chen who walked away with the biggest prize. By combining computer modeling and biological studies, Chen's research focused on leads for a "new type of anti-flu medicine" to help fight the spread of the influenza virus. Australian Viney Kumar and Canadian Ann Makosinski took home awards for an early warning app for oncoming emergency vehicles and a flashlight that operates without batteries or moving parts, respectively. This year, voters got the chance to affect the outcome, awarding a new prize to Elif Bilgin, from Istanbul, who showed it was possible to create plastic from banana peel. Each winner took home a trophy built from Lego, as well as prizes from National Geographic and Scientific American. Chen, however, walked away with a $50,000 scholarship, a trip to the Galapagos Islands and his school gets both $10,000 and a Hangout with the boffins at CERN. Well deserved, we'd say.
Vaccine-delivery patch uses microneedles to do its dirty work, looks good in testing
This dissolving microneedle patch has been in development for well over a year now, but Mark Prausnitz -- a professor in the Georgia Tech School of Chemical and Biomolecular Engineering -- along with a number of other GT and Emory University colleagues, have just now wrapped up a lab trial that brings it that much closer to market. As the story goes, this vaccine-delivery patch, which is based on hundreds of microscopic needles that dissolve into the skin, was recently seen as reliable in a round of mice tests, and the powers that be have also concluded that these patches would cost "cost about the same as conventional needle-and-syringe techniques, and may lower the overall cost of immunization programs by reducing personnel costs and waste disposal requirements." Oh, and did we mention that you could apply 'em on your own with little to no pain? FDA approval, we're waitin' on ya.
Breast cancer vaccine proves successful in tests on mice, moves on to human subjects
Here's a cause for optimism, albeit the cautious kind. Researchers at the Cleveland Clinic Lerner Research Institute have managed to isolate a human protein that plays part in the development of breast cancer, and have produced a vaccine against its creation that has delivered an impressive success rate in testing on mice. In a test group of genetically cancer-prone rodents, none of those injected with á-lactalbumin developed the potentially deadly disease. The progress of this drug trial to testing on humans has been met with reservation by cancer research groups, who remind us that we're years away from knowing if it will actually work on our species. Still, this is quite the little breakthrough and we hope all goes according to plan.
Ceramic microneedles to make injections painless
Rest assured, we've "seen" methods of delivering injections sans pain, but we've yet to actually experience this phenomenon ourselves. If Dr. Roger Narayan has anything to do about it, however, we may not feel even a pinch the next time the blood drive comes calling. A team of researchers led by the aforementioned individual has reportedly been able to use "two-photon polymerization of organically modified ceramic (Ormocer) hybrid materials to create microneedles resistant to breakage," and they can also be made in a wider range of sizes than metal counterparts. It's said that these very needles would be "so fine that patients wouldn't feel them piercing their skin," and while that sure sounds delightful, we've no idea how many more visits we'll make before finding one of these in the nurse's hand.[Via medGadget, image courtesy of Rice]
LG's Vaccine USB flash drive keeps your machine disinfected
We've already taught you to not use syringes USB flash drives that you find on the street, but we know all sorts of unwanted invaders can meander on into your hard drive when you're not looking. Enter LG's aptly-named Vaccine USB flash drive, which comes pre-loaded with anti-virus / malware protection software and provides "real-time system monitoring and hardware scans." Aside from making sure your rig doesn't catch any bugs going around, it also updates itself when plugged in to an internet-connected PC. Regrettably, we've no idea how much these things will cost (nor if Medicare will cover), but they will be offered up in sizes ranging from 512MB to 8GB.[Via EverythingUSB, image courtesy of Pocket-Lint]
NanoPass needles set to vaccinate sans pain
Given the choice, even we'd take the pills over the vaccination, but a new Israeli startup is hoping to ease the fears so commonly associated with needles. NanoPass Technologies is working to develop its "proprietary intradermal drug delivery technology," which supposedly deliver injections without the painful side effects by actually not reaching the nerve endings of the skin. Based on MicroPyramids, which are manufactured by MEMS (Micro Electro Mechanical Systems), the pure silicone crystals are used in extremely diminutive microneedles for intradermal injections, and the tip of the device measures less than one-micrometer in diameter. The company touts its pain-free technology (sound familiar?) as a breakthrough that is "non-intimitdating," which should reduce the likelihood of fainting both youngsters (okay, and adults) face when dealing with needles, and is even said to be easier to administer. Unfortunately, we've got no good news proclaiming that these will be replacing intramuscular and subcutaneous methods later this week, but the $6.5 million in funding that the company has acquired should go pretty far is helping its cause. [Via MedGadget]
