FoldersSynchronizer, the backup and sync utility from softtoBe, has been updated to version 3.6, with the addition of Universal Binary status. This is one of the first backup utilities I ever found - I subsequently bought a license way back in the day and it's always done the trick for me since.
I've never seen it appear on any 'best utilities' lists, but its extensive feature set seems to match most of the other similar apps I've seen. Users can back up an entire Mac OS X volume and make it bootable. In addition, FoldersSynchronizer has extensive support for multiple backup sessions and configurations, synchronizing directories as well as backing up, setting backup timers, automounting volumes, filtering files and much more.
A demo of FoldersSynchronizer is available, while a full license will cost $40.