I'll be the first to admit that Twitter, which we at TUAW totally heart, isn't for everyone. Quicksilver, another TUAW fav, is also not for everyone. However, when you cross Twitter with Quicksilver and throw in a dash of Growl and you've just made it onto my Christmas card list.
First Coda Hale whipped up a QuickSilver action, using AppleScript, enables you to post tweets (that's what messages posted to Twitter are called) using only QuickSilver. Then Ted Leung took the same script, but added Growl notification which lets you know when the tweet has been posted via Growl.
I may be in geek nirvana.