Ambrosia Software has released WireTap Anywhere 2.0, an upgrade to the company's professional audio routing and mixing software. Following up on the 2008 release of version 1.0, this upgrade claims that "hardwired is out; softwired is in" and allows users to capture, map, and independently adjust audio channels from any combo of applications or input devices and route it to the audio processor application of your choice.
Interested in recording your Skype conversations or sending some real-time QuickTime audio to a friend in iChat? WireTap Anywhere 2.0 can do that, allowing users the ability to mix and match any combinations into a single recording application. I have been a user of Audio Hijack Pro from Rogue Amoeba for years, and this looks like a solid competitor in the audio capture niche.
While you can try it out free for 30 days, WireTap Anywhere 2.0 for Mac OS X 10.5 or later is available to new users for US $129 or as a $69 upgrade for registered users of WireTap Anywhere 1.x.