Inquisitive Nintendo president Satoru Iwata will be keynoting the Game Developers Conference this year. The keynote is entitled "Video Games Turn 25: A Historical Perspective and Vision for the Future," and celebrates the 25th GDC, which takes place this March. Gamasutra notes that Iwata will speak "not only about how video gaming has evolved, but also his views on where we go from here."
Of course, the stage also offers an opportunity to talk about new Nintendo products. Given the timing, we'd say it's the perfect place to showcase Nintendo's most anticipated product, the Vitality Sensor.
... But seriously, he's going to talk about the 3DS.