Combit Studios has announced that it will be partnering with River City Ransom EX developer Million to create "an official, worldwide follow-up to River City Ransom." The game will be available for Windows in August of 2014, according to Combit's official blog.
Further information will be released at a later date, leading up to an eventual crowd-funding drive scheduled for sometime this summer. In the meantime, an official placeholder website will gladly add your email address to its mailing list.
Combit Studios' project appears to be completely unrelated to that other official sequel to River City Ransom that was announced back in 2011. Developed by Miracle Kidz and originally slated to launch on WiiWare sometime last year, River City Ransom 2 was shelved in favor of original projects.