DrugDelivery
Latest
Researchers power tiny medical implant from over 100 feet away
Researchers at MIT are working on tiny implantable devices that can communicate and be powered wirelessly. In the future, they could be used to deliver drugs, treat disease or monitor conditions from inside a human body. Because the devices don't require a battery, they can be pretty small and the prototype the research team has been working with is about the size of a grain of rice. But the researchers think they can get the devices to be even smaller than that.
Researchers use sperm to deliver cancer drugs to tumors
Chemotherapy has a lot of terrible side effects and that's partly because the drugs being used to fight cancer also attack healthy cells. Figuring out a way to deliver drugs to tumors without affecting healthy tissue is a challenge and a problem that researchers are trying to solve. One group working on this problem, New Scientist reports, is a team at the Leibniz Institute for Solid State and Materials Research Dresden and in a recent study, they showed that sperm could be turned into an effective drug delivery tool.
DNA 'computers' could lead to self-activated smart pills
Imagine a pill that knew if you were ill enough to need drugs, and wouldn't release chemicals if it thought you didn't need it. That's the breakthrough that's been made at Eindhoven University in the Netherlands by a team of researchers ld by Maarten Merkx. The team has harnessed the power of DNA itself to form an organic computer that performs crude calculations on the state of your health.
Mind-controlled nanobots release drugs inside cockroaches
Stay with me here -- scientists from Bar-Ilan University and the Interdisciplinary Center in Israel created nanobots, injected them into cockroaches, and released fluorescent drugs into the insects using mind power. While that sounds insanely convoluted, the aim is to actually help humans. If a schizophrenia patient is about to have a violent episode, for instance, an EEG could trigger the release of powerful drugs. That way, they'd only get them when needed, minimizing harmful side effects.
Scientists use nanoparticles to crush lingering fat cells
If you think losing weight is simply diet plus exercise, the equation is not so simple. A recent study of Biggest Loser participants showed that even if you manage to drop pounds, your body will fight you for years afterward to gain them back. That's why scientists have put so much effort into studying obesity in an effort to help us fight our own genes. Researchers from MIT and Brigham and Women's Hospital think that our ubiquitous friends, nanoparticles, could deliver drugs to specific parts of the body, turning bad fat cells into good ones that burn fat.
MIT engineers use ultrasound for improved topical drug administration (video)
Ultrasound is likely most often associated with sonograms, but some MIT engineers are poised to change that. By using two separate beams of inaudible sound waves (one at low-frequency, the other high) the team were able to increase the permeability of skin, in a bid to improve the efficiency of transdermal drug delivery. The technique works thanks to the waves exciting bubbles in a fluid (such as water), forcing them to swell and move chaotically. Once the bubbles reach a certain size they implode, sucking the surrounding fluid into the void. This process creates micro-jets of liquid, which cause miniscule tears in the skin, allowing it to (painlessly) absorb chemicals more effectively. In practice, a pre-treated area of skin is then covered with a patch containing the correct dose of drugs -- but don't worry, the skin is said to grow back just a few hours later. Up until now, research into ultrasonic administration of drugs has concentrated on low-frequency waves, because the higher end of the spectrum doesn't have enough energy to pop the bubbles. Higher frequencies do, however, help create more of them and also limits their lateral movement. By using both high- and low-frequencies, the MIT engineers found this produced better over all results, by not only increasing the skin's uptake of the medicine, but also increasing the number of drugs that can be delivered this way. With pretty much anything that is usually delivered in capsule form being on the cards, this could make the administration of many popular drugs much more convenient and / or effective. Also excellent news for those who really don't like needles.
MIT duo successfully tests wireless drug-delivery microchips, more consistent than injections
Despise those daily injections of essential medication? Well folks, relief could be on the way. Over a decade ago, two MIT professors, Robert Langer and Michael Cima, first considered developing a drug-delivery microchip that could be wirelessly controlled. This past week, researchers in Cambridge -- alongside scientists from MicroCHIPS, Inc. -- announced that they have successfully used the aforementioned chip to give osteoporosis patients their daily allotment of teriparatide. "You can do remote control delivery, you can do pulsatile drug delivery, and you can deliver multiple drugs," Langer noted. Chips used in this particular study housed 20 doses each and results indicated that the delivery showed less variation than administered injections. In theory, microchips like these could be used alongside sensors that monitor glucose levels -- creating tech that could adapt to changes in a patient's condition. More info on the trial awaits in the source link below.[Thanks, Lydia]
NC State gurus find 'Goldilocks' of DNA self-assembly, look to improve drug-delivery vehicles
We're guessing that most Wolfpackers in the greater Raleigh area are in full-on tailgate mode right now, but aside from laying a beating on the Seminoles this evening, NC State faithful are also trumpeting a new DNA discovery that could one day make it easy to get vital drugs to hard-to-reach places within you. Researchers from the university have purportedly discovered the 'Goldilocks' of DNA self-assembly, which holds promise for technologies ranging from drug delivery to molecular sensors. The concept, known as DNA-assisted self-assembly, has been vastly improved by using "computer simulations of DNA strands to identify the optimal length of a DNA strand for self-assembly." You see, perfection occurs when strands aren't long enough to intertwine with each other, yet not short enough to simply fold over on each other. We know, it's a lot to wrap your brain around with half a hot dog shoved in your mouth, but hit the video after the break for a... shall we say, more visual explanation.
The PatchPump wearable drug-delivery system
The number of medical gadgets we've seen to ease medicine delivery is pretty staggering, with everything from the simple (digital pill box) to the insane (drug-infused false teeth). Now it looks like Israeli outfit SteadyMed is ready to enter the fray with the PatchPump, a wearable battery-powered drug pump that hits you with a constant dose of your prescription throughout the day. The system is based around a unique battery that gets bigger as it depletes, providing both the power supply and the motive force behind the pump. SteadyMed is working on version of the PatchPump that last from 48 hours up to 7 days, but there's no word on when these might hit hospitals.[Via MedGadget]
