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Lab-on-a-chip aims to take suspense out of blood work
If your doctor's ever uttered the words, "I'd like to run more tests," you know the wait for results can be torturous. Engineers and students at the University of Rhode Island (URI) are hoping to stop the torture with a new lab-on-a-chip technology that cuts way back on the wait for important lab results. The system provides results in 30 minutes, using a portable device and just a drop of blood. The blood is placed on a small plastic polymer cartridge, smaller than a credit card, and inserted into a shoebox-sized biosensor. It then travels across the cartridge to a detection site where reagents enable the sensor to detect biomarkers of disease. Basically, your doctor pops a bloody piece of plastic into a box, and out come your results. The first cartridges were developed to assess the risk of heart disease, but researches suggest they could be designed to detect everything from HIV to Alzheimer's. The URI team estimates costs at $3200 for the sensor and $1.50 for the test. No official word on a release date, but we hope they won't make us wait too long -- we can't stand the suspense.
Looking at death knight changes testing in PTR Patch 4.0.6
There are changes on the upcoming 4.0.6 PTR for death knights. Actually sorting through them may prove a little difficult, as the official patch notes and the datamined information sometimes say two different things. In short, though, we can say that blood has received a bit of a survivability hit, but a nice threat boost; unholy has both become a more solid 2H damage tree and received a sizeable (but expected) DPS nerf; and 2H frost has gotten a nice boost that may actually make it viable in endgame raiding, depending on how the numbers hold out. Remember, though, that this is the PTR, and things may (and probably will) change before this thing goes live. With that in mind, let's take a look at what the changes say.
Withings fittingly debuts iPhone-connected blood pressure monitor at CES
Trust us -- no one on the Engadget staff wants to know what their blood pressure is right about now. For those trapped in the hurricane that is CES, there's probably no better product to have laying around than this... but only if you're looking to confirm your suspicions about being in a high-stress career. Withings, the company best known for its connected scales, has just revealed the planet's first iPhone-connected blood pressure monitor, with an aim to make measuring vitals as easy as pie for iOS users. The idea is fairly simple: just plug the arm band into your iPad, iPod touch or iPhone, dial up the gratis app and start the process. All of the data is logged on the user's secure online space, and there's even a secure sharing feature that'll beam your abnormally high rates right to your frightened physician. It'll go on sale tomorrow around the globe, with the asking price set at $129 / €129. Update: Looks like iHealth beat these guys by a dozen hours or so. Splitting hairs, but there it is. %Gallery-112205%
Researchers develop 'blood camera' to spot crime scene stains in a flash
Could inspecting a crime scene for even the most minuscule blood stains one day be as simple as taking a picture? It will if some research now being conducted at the University of South Carolina in Columbia pans out. A team there led by Stephen Morgan and Michael Myrick have developed a so-called "blood camera" that uses a combination of infrared light and a transparent layer of the protein albumin -- the latter of which acts as a filter and is able to highlight blood stains by filtering out wavelengths that aren't characteristic of blood proteins (or so we're told). That's as opposed to current methods for detecting blood at a crime scene, which rely on the chemical luminol to make the stains appear in the dark. As New Scientist notes, however, that method can also dilute blood samples and make DNA difficult to recover, and create false positives. The researchers don't seem to be stopping at blood, though -- they say the camera could also be easily adapted to detect trace amounts of other materials that aren't visible to the naked eye, like drugs or explosives.
Lichborne: Death knight regemming and reforging for patch 4.0.1
Every week, WoW Insider brings you Lichborne for blood, frost, and unholy death knights. Now that we've had a bit of time with patch 4.0.1, hopefully you've settled in to a decent rotation and spec and have begun to feel your way around the new system. Now that you've done that, there's one more step to take: figuring out the best way to reforge and regem your gear. Reforging can be done through certain NPCs in major cities and is a process whereby you take one secondary stat (the ones in green text) and reforge part of it into another stat. This process can be very useful for getting rid of extra stats past the soft cap or just plain getting rid of stats that aren't important for your class or spec. You can't reforge a stat into another stat that's already on the item, but otherwise, your possibilities are endless. Gemming remains more or less how it always has. The one big, new curveball we've been thrown is the fact that hit gems are now blue. This is probably overall a win for DPS death knights, as it gives us a few more options to aim for gear bonuses without handicapping ourselves as much. To understand how, when and if to regem and reforge your gear, you'll need to understand stat weights. While it's still pretty early in the 4.0.1 game (and therefore, it's not completely clear what stat weights are for every spec), the death knight community has still done enough math that we're relatively certain of the general order. With that in mind, let's look at every spec and figure out the best ways to regem and reforge.
The Art of War(craft): Must-have PvP talents for death knights in 4.0.1
Every week, WoW Insider brings you The Art of War(craft), covering battlegrounds and world PvP, and Blood Sport for arena enthusiasts. Want to crush your enemies, see them driven before you and hear the lamentation of their women? Battlemaster Zach Yonzon, old-world PvP grinder and casual battleground habitué, rambles on about anything and everything PvP. So the bomb finally dropped. As expected, Patch 4.0.1 finally made it to live realms and players are scrambling to get used to everything new. For most players, that first free respec is used for PvE to enable them to join the latest PUG looking to down the week's raid boss. This is when reality bites -- that spec you've been fiddling around with over at Wowhead or wowtal.com isn't delivering the way you thought it would. That's OK. If you're doing some PvP, understand that there are a number of bugs out there, so things aren't behaving exactly as they should. Add to that the fact that the game is balanced around being level 85, that stamina is low, and resilience has taken a hit ... things are going to be somewhat wonky. So don't write off that spec you've theorycrafting on for weeks just yet. Since specs are pretty complex and fluid at this point, we'll take a look at vital PvP talents instead. The fun thing is that at this point in the game, all specs are good to go for PvP -- although your mileage may vary. There isn't much room for variation, unlike before, when players could reach deep into two trees, especially for PvP. But inevitably, there are talents that are extremely useful in a PvP environment. Today we'll take a look at core PvP talents for each spec for death knights, just in case you were wondering what to do with those last few talent points. For this exercise, we won't bother discussing any 31-point talents because, well, you're supposed to pick those up, anyway.
Murata's fatigue sensor demoed, coming soon to mobiles and handhelds near you
Need further confirmation that an IV drip of 5-Hour Energy is what your body really needs? Look no further than Murata's newfangled fatigue sensor. Demonstrated at CEATEC in front of thousands of jetlagged Americans, Europeans, Easter Islanders and Samoans, this compact device is built by "integrating a photoplethysmographic sensor, which measures a pulse and a blood oxygen saturation level, and electrodes that measure electrocardiogram (ECG)." We're told that the unit measures a fatigue degree (reported on a 1 to 100 scale) based on the "pulse, blood oxygen saturation level and electrocardiogram measured by the sensing parts," and while we're guessing the prototype will have to shrink significantly before it happens, the company seems focused on cramming this thing into cellphones and portable game consoles of the future.You know -- so Nintendo actually can know when you need to lay down the gaming and step outside for a bit.
GOG discounts some unexpected 'Atari classics'
When someone says "Atari classics," what games do you think of? Stuff like Master of Orion, Alone in the Dark: The New Nightmare and One Unit Whole Blood, right? Of course. Well, even if that isn't the case, let that be your working definition for now. GOG is offering a promotion for a selection of Atari PC games, including those mentioned above and more (the full list is after the break). Each game has been marked down to four bucks and change, or you can grab the whole set of ten for $31.90. The deal is active through October 11.
Newest class revealed for Mythos encourages others to give blood
Mythos, the upcoming Diablo-style action MMO, has not shown its first three classes to be subtle creatures. The first two revealed, the pyromancer and the gadgeteer, both showed their aptitudes for wide-scale destruction. However, the newest class reveal is even more direct -- the bloodletter. It's both a class name and description of what the class specializes in doing. This class is a master of blood and causing grievous bodily harm to everything within range, and it seems quite well-suited to doing just that. As with other classes, the bloodletter has three different specializations available. The crimsonate gouges opponents and derives sustenance from their injuries, the red hand uses a necromantic control of blood to summon minions and turn corpses into weapons, and the martialist discards pseudo-mystical abilities in favor of brutal expertise with weaponry. Take a look at the full class page for preview screenshots as well as short movies demonstrating the class capabilities, all fine demonstrations of what to expect from what may be the most direct class in Mythos.
Lichborne: Unholy and the state of the Cataclysm beta talent trees
Welcome to Lichborne, your weekly source for news, guides, tips and opinions on the death knight class. With this week's Lichborne, I was hoping to have run a few heroic Cataclysm dungeons so I could report back to you on how death knights play through them -- but alas, it was not to be, as my beta client refuses to log in to the game without crashing. Luckily, there are plenty of things to discuss apart from that. This week, I'd like to discuss our talent trees as they currently are in the beta and where things are headed for us as the release date draws nearer.
Cataclysm Beta: Build 12984 death knight changes
In the wee hours of the morning, an (as yet unimplemented) beta build found its way out onto the internet for dissection by the usual datamining suspects. As has become a happy habit with the past few builds, there are death knight changes to be had. Now, these changes don't solve all of our problems. In fact, some of them exacerbate a few of them. However, a couple of the changes are amazingly good, and I'd call this patch, overall, another step in the right direction. Let's take a look at what changed and what it means for the death knight playstyle. As a warning, this patch has not yet been placed on the beta as of this writing, so things may still change from what's here.
Lichborne: Death knight changes for Cataclysm beta build 12942
Welcome to Lichborne, your weekly source for news, guides, tips, and opinions on the death knight class. Cataclysm beta build 12942 is now on the beta servers, and with it has come a much-anticipated, huge round of death knight changes. There's some deceptively minor stuff, some incredibly game-changing stuff and a lot of in-between stuff. Let's take a look at the changes (some gleaned from in game, some courtesy of MMO Champion) and see what we can figure out about where the death knight class is headed.
Lichborne: Death knight beta diaries, part 3: Blood leveling in Vashj'ir
Welcome to Lichborne, your weekly source for news, guides, tips and opinions on the death knight class. As things currently stand in Cataclysm, much of the death knight's famous ability to take tons of punishment and get health back, even in DPS mode, has been removed with the removal of health stealing from the main DPS presence. Unholy and frost death knights will find themselves resorting to using the less damaging (for them) Death Strike while leveling to stay alive and lessen downtime. Of course, there is one spec that still maintains much of the health-stealing power of our Wrath heyday: blood.
DARPA has artificial blood; Cullen family stock upgraded to 'buy'
A few years ago, DARPA teamed up with a company called Arteriocyte to research methods for manufacturing blood without an actual donor on-hand, and whaddya know -- a million and change tax dollars later, here we are. You no doubt remember stem cells. Well, they're back in a major way (did they really ever leave?), and this time instead of clogging up the Supreme Court's backlog they're helping manufacture blood that is "functionally indistinguishable" from the real type-O. "Pharmed" blood (their word, not ours) will eventually be a godsend for troops in the field, where fresh blood often takes three weeks to arrive from the source. But don't cancel all your donor appointments just yet -- eBlood (our word, not theirs) won't be ready for human testing until 2013. And pints still cost more than a bottle of Johnny Walker's finest -- around $5,000, and that's before they factor in the cookies and apple juice they gave the umbilical cord for its time and patience.
GPS parachutes delivering blood to front lines in the coming years
GPS-guided parachutes are nothing new -- in fact, we're guessing that a few are being dropped somewhere in this wide world right now -- but a new deal between the Armed Services Blood Program and US Joint Forces Command will allow these devices to start saving even more lives in 2011. As the story goes, a cadre of air-dropped 'chutes will be sent to the front lines of the battlefield in order to deliver vital blood to medics. For those unaware, blood loss is a major cause of death in war, and by skipping over the lengthy process that's currently in place for delivery, the powers that be feel that more soldiers can be saved. Reportedly, the JPADS system "is a family of guided parachutes that can carry payloads ranging from about 150 to 60,000 pounds," and at a predetermined altitude, a "parafoil deploys and a GPS-device steers supplies to an exact target." The new system, however, will rely on ultralight versions of the aforesaid JPADS in order to sneak into locations that were previously thought impossible to penetrate. 'Course, all of this will be a moot point once the robot armies rise to power and start pulverizing each other with scrap metal, but hey...
Lichborne: The new blood tree in Cataclysm
Welcome to Lichborne, the weekly death knight column for the class undergoing some pretty cataclysmic changes to its setup and philosophy in the new expansion. With the Cataclysm beta out of NDA, we've had a chance to take a look at some of the new death knight changes coming our way. I'm pretty sure (and hopeful) that they're not complete yet, but there's enough of it done that we have a relatively good chance of figuring out where it's going. We'll start our more in depth look into the new sole tanking tree of the death knight class, blood. Blood is shaping up to a very interesting tanking tree. If there's one way I can sum it up, it's this: For all that Blizzard's said they want to move away from the "AoE everything down" model, it's interesting that they've done a lot of work to shore up blood's AoE talents. Let's take a look at some of the ways blood is changing in Cataclysm.
Cataclysm: Reaching uncrittable
For those of you who don't know much about tanking, we're going to talk quickly about a stat that won't exist in Cataclysm. This lowly stat is called defense rating, and it's something that tanks need quite a bit of. The nice thing is that it's on just about everything that tanks wear, which means at higher gear levels, we've got it coming out of our ears. The primary point of this stat is to reduce the critical strike ability for incoming melee hits from the standard of 6% to 0%. Druids currently don't need this stat, as they've got a talent called Survival of the Fittest, which means that bosses don't need to drop defense leather. All in all, the stat is kinda boring, as while it does still do nice things after you reach the defense cap of 690 rating (or 540 skill), most people don't bother with it and stack stamina or other avoidance. So Blizzard decided that they're going to get rid of it. Around BlizzCon 2009, we were told that the crit reduction we formerly got from defense rating was going to be tied into things that were available to all members of each tanking class. Examples used were baking it into Bear Form for druids, Righteous Fury for paladins, Defensive Stance for warriors and Frost Presence (or rather, Blood Presence in Cataclysm) for death knights. That means that if a retribution paladin or arms warrior wanted to tank, all he'd need to do was swap to vaguely appropriate gear (or just over to a sword and shield), pop his respective abilities, and away he'd go. That's not how it appears things went down, though.
Lichborne: Glyphs, gems and enchants for the blood tank
Welcome to Lichborne, your weekly peek into the latest news, tips and strategies for the death knight class. Last week, we went into the basic outlines of what makes a blood tank: your talent choices, your gearing choices, your threat rotations and things such as that. Once you've got all that down, though, the next thing you can do to take your tanking to the next level is to get some decent gems, glyphs and enchantments. They'll separate an adequate 5-man tank from a tank who's ready to step on and start taking on the game in earnest.
Lichborne: Blood tanking 101
Welcome to Lichborne, your weekly journey into the world of the death knight. This week, we're getting ready for Cataclysm in our own round about way. While sometimes less considered by the WoW population at large, blood tanking has long been known to serious players and theorycrafters as an incredibly dominant raid tanking spec, thanks to incredibly high health pools. It will also be the sole tanking tree for death knights in Cataclysm. While it is certain that the tree will change extensively under this new system, it is likely to have a lot of the same elements in place that make it distinctively blood tanking, even in the new expansion, so it might not hurt to start practicing with it now. Whatever your reason for trying blood tanking, this guide is here to help you take the first few steps along that path. Remember as this is a 101 guide, we won't necessarily being doing hardcore theorycrafting, and we may simplify a few basic concepts that can be a bit more nuanced for an experienced, high-end blood tank.
German researchers develop biotech sensor bracelet, disposable blood lab
Biochips -- flexible, disposable plastic circuits that "compute" via chemical reaction -- have been nearing reality for over a decade, but for obvious reasons we don't always pay attention. German research institute Fraunhofer IZM has just convinced us it's high time we did. This week, the organization announced that it's on the verge of creating a lab-on-a-chip that can diagnose deep vein thrombosis from a single drop of blood, as well as a wristband that can measure body temperature, skin moisture and electromagnetic radiation using plastic chips and sensors only micrometers thick. Impressive, yes, but the real news is the production process -- these gadgets can be printed in reels and sheets. The organization imagines the tools will be so cheap they'll be disposable; rather than wait for lab results, worried individuals will just take one out, test and toss to feel confident about their bloodwork, before hopefully going back to their normal lives.
