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World's smallest nanomotor can pump drugs into cells at 18,000 RPM
Scientists at the Cockrell School of Engineering in Texas have created a nanomotor less than one micrometer in diameter, smaller even than a cell. Powered by electric fields, it consists of a nanowire, magnet and electrode and can spin at a terrifying-sounding 18,000 RPM for over 15 hours (see video below). That's as fast as a jet engine, but don't worry (much). During testing, it showed the ability to pump fluids at hyper-fast speeds and to move around freely in other liquids. That opens up beneficial applications like highly controlled insulin delivery, or devices that could specifically target malignant cells. Of course, that would mean you'd have to let intelligent nano-devices with mini-saws roam about your body -- I guess you're allowed to be a bit terrified.
Clicking Bad is the darker side of Cookie Clicker [Update]
The latest strangely enticing phenomenon, Cookie Clicker, rewards players with cookies for every click of the mouse. Among the list of things more addicting than cookies is methamphetamines, the drug central to the plot of the popular, recently ended TV show Breaking Bad. Capitalizing on both properties is Clicking Bad, a free browser game in the same style as Cookie Clicker that has players cooking up drugs and selling them to upgrade their equipment. Clicking Bad launched its public beta roughly a week ago and just recently hit version 0.6, which added more manufacturing and selling tiers as well as changing the cost structure. The game tasks players with managing their drug creation business by either manually clicking "buy" and "sell" buttons or using in-game money to purchase upgrades like sleazy lawyers and abandoned trailers, each providing a boost to sales or production. The upgrades may also impact the odds of authorities catching on and seizing your meth-cooking labs as well as the purity levels of your drugs. The game's Twitter account notes that an achievement system "may or may not make it in this week," indicating that more updates are on the way. We're waiting for the right moment to introduce Clicking Bad to our own Richard Mitchell, who recently opted to stream his Cookie Clicker obsession for all to pity. We're worried about him enough as it is. Update: The game has just been updated to version 0.7, and sure enough, it now includes achievements.
Timothy Leary-developed video games found in New York Public Library archive
The New York Public Library recently discovered a treasure trove of video games in its archives created by psychedelic evangelist Timothy Leary. Over 375 floppies (talk about flashbacks) containing a "dozen or so" games developed by the LSD-advocate in the '80s -- some are playable via emulation -- are now on display in the library's rare books and manuscripts division, according to The New York Times. The good doctor's digital works had a self-help bend to them, advocating self-improvement by interactive means as opposed to pharmaceuticals, and apparently recreational drugs as well. If you fancy yourself a cyberpunk, Leary also had an in-progress project based on William Gibson's Neuromancer, replete with writing by William S. Burroughs and a soundtrack by Devo. He had more than just prototypes, too: His Mind Mirror was commercially released in 1985 and sold 65,000 copies for publisher Electronic Arts. If you can't make it to the NYPL, a version has been adapted to Facebook so you can glean your personality profile from your... profile. [Image credit: Jaycobs / Flickr]
Saints Row IV loses 'alien narcotics' mission to gain approval in Australia
We knew the Australian Classification Board had fundamental objections to Saints Row IV. What we didn't know, however, was that these sticking points boiled down to just a single 20-minute side mission, in which the player gained superpowers by smoking "alien narcotics" with a character called Shaundi. That mission has now been exorcised, microwaved and buried in a sanitary disposal tank somewhere in the outback. According to Eurogamer, the only other change to the Australian version of Saints Row IV is the removal of a weapon called the Rectifier, which the censors were too anal to appreciate, but which will still be available to players as DLC. Meanwhile, we're taking bets on how long it'll be before the full, uncut title hits shelves Down Under as a premium box set.
PocketPharmacist for iOS now lets you refill Walgreen prescriptions
This is an idea I've thought would be useful for a long time, and now a developer has gone forth and brought it to life. The PocketPharmacist app (US$1.99) has been long appreciated for drug information and drug interaction data, and now has the ability to refill a Walgreens prescription right from the app. Walgreens also has a free app that does this, but without all of the helpful drug information. "People continue to become increasingly engaged with their mobile devices and use the technology to help make their day-to-day lives easier," said Abhi Dhar, Walgreens e-commerce chief technology officer. The new medication refill feature enables PocketPharmacist users to refill a Walgreens prescription within seconds. "PocketPharmacist is thrilled to offer iOS users both the convenience and ease of refilling their Walgreens prescriptions," said Michael Guren, founder and CEO of Danike, Inc. "We believe this adds to our goal of helping people better understand and manage their medications." The app takes no advertising from pharmaceutical companies, so the information is unbiased. The app covers a total of 1530 drug summaries, and all current FDA information. There is also an extensive database on drug interactions. PocketPharmacist is optimized for the iPhone 5 and requires iOS 5 or greater. %Gallery-177956%
Georgia Tech models swimming, cargo-carrying nanobots
The nanobot war is escalating. Not content to let Penn State's nanospiders win the day, Georgia Tech has answered back with a noticeably less creepy blood-swimming robot model of its own, whose look is more that of a fish than any arachnid this time around. It still uses material changes to exert movement -- here exposing hydrogels to electricity, heat, light or magnetism -- but Georgia Tech's method steers the 10-micron trooper to its destination through far more innocuous-sounding flaps. Researchers' goals are still as benign as ever, with the goal either to deliver drugs or to build minuscule structures piece-by-piece. The catch is that rather important mention of a "model" from earlier: Georgia Tech only has a scientifically viable design to work from and needs someone to build it. Should someone step up, there's a world of potential from schools of tiny swimmers targeting exactly what ails us.
Cooking Mama: Breaking Bad is the good stuff
Sure, Breaking Bad is a show about the crippling stress and fractured interpersonal relationships of running a high-stakes meth-cooking operation, but it's a show that makes us want to experience that kind of mind-melting trauma firsthand. And now we can, thanks to Cooking Mama: Breaking Bad.Developed by Juan David Gómez, Cooking Mama: Breaking Bad lets players partake in the joy of mixing dangerous chemicals into grade-a meth, without all the hassle of killing your rivals, evading the authorities and losing the love of everyone you ever cared about. Play a few rounds in your browser right here.
FDA approves Proteus Digital Health's e-pills for dose monitoring
An "ingestible sensor" doesn't sound like the tastiest of snacks, but soon it might be just what the doctor ordered. A tiny microchip which activates upon contact with stomach acid has recently been given the green light by the US FDA. When the sensor is swallowed, an external patch picks up its signal and shoots a message over to whoever it's supposed to. The technology is aimed at tackling an issue known in the healthcare biz as compliance -- or, following instructions. Correct timing and dose are important for many drugs, and lax schedules can be responsible for treatment failures or the development of nasty drug-resistant bugs. Although the pills have only been used in trials, one pharmaceutical heavyweight has already bagged a license to the technology for real-world applications. If you don't like the thought of a belly full of microchips, no need to worry -- the harmless sensors pass naturally after completing their mission.
The Daily Grind: Do narcotics belong in MMOs?
Be it a sci-fi cantina or a fantasy tavern, your MMO's local watering hole no doubt offers a very specific sort of drug: alcohol. But you might have noticed that non-alcoholic drugs aren't usually given the same chance to virtually corrupt you as do more comfortable vices like extreme violence, gore, thievery, and physics-defying cleavage. Immersion-centric players might argue that narcotics add to the gritty realism of many game worlds and aren't really different from other mind-and-body-altering substances like booze, but developers seem wary of wading into that territory. Star Wars Galaxies, for example, launched with canon-correct spice (complete with "downer" effects) but ended spice production with the NGE. And Lord of the Rings Online implemented Tolkien's famous pipeweed but has resisted bestowing beneficial effects on those who smoke it, probably for fear of encouraging "bad" behavior, triggering political drama, or jeopardizing its age rating. What do you think -- do narcotics belong in MMOs? Every morning, the Massively bloggers probe the minds of their readers with deep, thought-provoking questions about that most serious of topics: massively online gaming. We crave your opinions, so grab your caffeinated beverage of choice and chime in on today's Daily Grind!
Mortal Online's CEO has high hopes for the game's subscriptions
A game company's CEO should always promote the company's games and be enthusiastic. There is such a thing as too much enthusiasm, however. Case in point: StarVault CEO Henrik Nystrom's comments during an IRC chat with fans. The chat was meant to cover the game's next major update, Awakening, but it included fan questions for future updates as well. It also included Nystrom telling a fan that he sees Mortal Online having roughly as many players as EVE Online in five years. By way of elaboration, EVE Online currently has roughly 450,000 players. Mortal Online's subscription numbers have never been revealed, but estimates place it under 10,000 players. An impossible goal? Definitely not, but certainly one that might be a bit overly ambitious. Fans of the game can still take a look at the chat for other interesting tidbits, however, including plans to add drugs and improve the new player experience in the future. [Thanks to Sandboxer for the tip!]
EVE Evolved: Risk vs. reward in lowsec
In EVE Online's early years, one of its core design philosophies was adherence to a strict risk vs. reward balance scheme. There were riches out there to be found, but to get them, you had to put yourself in the firing line. Police ships patrolled high-security space to keep players safe from piracy, but the only resources available there were low-bounty frigate NPCs and inexpensive ores like Veldspar, Scordite and Omber. In the lawless far-reaches of nullsec, huge NPC bounties and rare ores containing Megacyte and Zydrine tempted hundreds of pilots to head out and make their fortunes. Nullsec offered absolutely no protection against player attacks, and the only safety to be found was in sheer military force. The biggest and best corporations hoarded these gold mines for themselves, locking down the few entrances into the regions and patrolling the skies for unwanted visitors. Low-security space offered a middle-ground between these two extremes, a place where the everyday pilot could enjoy increased income and pirates were easier to spot. At some time in the past nine years, lowsec lost its place in the game and became simply not worth the effort. But how did that happen, and what can be done to fix it? In this week's EVE Evolved, I look at why lowsec systems are now ghost towns and suggest an alternative design philosophy that I think could revitalise these under-used areas.
Transmog your way to a roguish look
I used to play a lot of Dungeons & Dragons in college, back when v.3.5 was all the rage. At the time, a series of companion books was being released with titles like Complete Adventurer or Complete Divine; these books listed additional abilities and classes that players could use to expand upon the core classes in the original D&D rule books. Warlocks, for example, were added in Complete Arcane as a spin-off from the mage core class. Instead of using classic D&D mage spells like Magic Missile, they used invocations, which the book provided. What I liked most about these books is that they made you think outside the box about your class. A warrior wasn't just a guy with a sword and a lot of armor proficiency; he could be a swashbuckler of the high seas or a graceful, dancing dervish. Both classes were warriors, but they fought in distinctively different ways. So when it comes to WoW and transmogrification, I think a lot about the possible archetypes certain classes could have and try to explore those in different outfits. Leather wearers, for example, don't always have to look like members of the Defias Brotherhood or the audience at a Grateful Dead concert. They could also be mud-splattered bandits, solitary rangers from the Hinterlands, or sneaky Warsong scouts. Oddly enough, today's outfit might just work for all three.
Inhabitat's Week in Green: Rolls Royce 102EX test drive, electric unicycle and a sun-powered leaf
Each week our friends at Inhabitat recap the week's most interesting green developments and clean tech news for us -- it's the Week in Green. Electric vehicle momentum swept the states this week as Inhabitat took a spin in the new Rolls Royce 102EX Phantom EV, and we brought you exclusive photos of BMW's brand new i3 and i8 electric cars. We also showcased six sexy electric vehicles set to hit the streets in 2012, watched a 350MPG EV win the Future Car Challenge, and saw scientists create the world's smallest electric vehicle from a molecule and four motors. Meanwhile, El Al airlines announced plans to launch a line of hybrid-electric Boeing 737 airplanes, Ryno unveiled a crazy electric unicycle, and a team of students revealed Uganda's first electric car. It was a big week for alternative energy as well as Kenya announced plans to tap lava power with a newly Toshiba-built geothermal energy plant and scientists made a breakthrough in using urine as a viable power source. We also looked into a scientist claiming to have achieved cold fusion, a 'solar cucumber' that harvests fresh drinking water from the ocean, and a sun-powered leaf capable of making ice in the desert. In other news, green textiles advanced by leaps and bounds as scientists wove fabric from 24-karat gold, researchers developed a reusable fabric that administers drugs through the skin, and the University of Kiel's developed a super-adhesive tape inspired by Gecko skin. We also showcased an incredible set of sculptures made from recycled circuit boards, we watched a crop of styrofoam robots invade Germany's streets, and we saw an innovative self-powered irrigation system win the 2011 James Dyson award. And just in time for the chilly winter season, we found these oh-so-handy texting gloves which feature conductive fingertips that allow you to touch, tap, or type on any mobile touchscreen outdoors without having to remove your gloves.
Researchers say nanorockets could deliver medicine quickly within the blood
Faster delivery is always better when it comes to pizza, Thai food and now... drugs? Doctors seem to think so as they're experimenting with a new method of delivering medicine to the bloodstream via tiny nanotubes powered by rocket fuel. By storing healing meds within the platinum-coated metal tubes, doctors have been able to propel the tiny vessels up to 200 times their own length per second -- faster than swimming bacteria. It works as such: by introducing a hydrogen peroxide/water solution, the platinum reacts, sending it zipping forward and catalyzing the peroxide into water and oxygen. The downside? Even though the fuel is only .25 percent peroxide, it's still slightly toxic -- so it looks like it's back to the drawing board until they can develop a safer alternative. Spiders, perhaps? Check out the video demonstration after the break.
Apple is worth more than all of these things
With Apple (AAPL) having a market cap of roughly US$387 billion, it becomes the most valuable company in the US. Matter of fact, it currently has a $30 billion lead over the next most valuable company, Exxon Mobil (XOM). However, market caps are boring. What's fun is to look at how much Apple is worth compared to other things. Like drugs, the Star Wars franchise and Denmark. That's exactly what the Things Apple is Worth More Than tumblr does. It turns out that at a market cap of $380 billion+, Apple is worth more than: All the illegal drugs in the world ($321 billion) The Star Wars, Harry Potter, Star Trek, Steven King, and Twilight franchises combined ($49 billion) The GDP of Denmark ($337 billion) and my personal favorite, the American obesity epidemic ($300 billion) The tumblr blog has more gems Apple is worth so be sure to check it out. It's an interesting list that really puts it in perspective just how much the Mac, iPhone and iPad maker is worth.
Researchers experiment with drug-delivering robot... implanted in an eye
If the notion of a tiny robot swimming around in your eye leaves you a bit uneasy then, well, you might want to stop right here. For the rest of you, though, you may be interested in some new tests now being conducted by Michael Kummer and his team of researchers at the Institute of Robotics and Intelligent Systems in Zurich, Switzerland. What you're looking at above is a pig's eye, and the tiny black spec near the top is a microbot that's able to roam around the eye with the aid of an electromagnetic system. While things are still obviously very early, the researchers say the microbots could eventually be used to precisely deliver drugs in humans, and treat issues like macular degeneration. Head on past the break for the video.
UCSF's robotic pharmacy automatically distributes medication, scrutinizes human error (video)
Robots are slowly taking over the world, right? Well, their latest conquest is the pharmacy. The UCSF Medical Center has implemented three robotic pill-dispensing machines that handle and prepare medication that's dangerous to the common human. The process works as follows: doctor writes a prescription, hospital clerk sends it over to pharmacist, pharmacist enters slip into the computer, robot picks up it and does the dirty work. The automated machine will grab the proper dosage, package it and slap a label indicating instructions and patient info. Rather than fearing for their jobs (or lives), the folks at the UCSF at are excited about this robot-takeover 'cause it increases the time care-givers spend with patients while allowing pharmacists to work more efficiently with physicians in determining what medication to supply. The most impressive thing, we think, is that our robot pals have not had a single error since preparing 350,000 doses of meds. Take that, meatbags!
Enzyme found to make fading memories fresher, old wounds painful again
There's something of a saying that you can only remember the things you try to forget, but if you'd prefer to hang on to those photographic moments from Thunder Mountain back in 1991, a gaggle of gurus from the Weizmann Institute of Science just might have the magic elixir you've been yearning for. According to a newly published study on long-term memory revitalization, Reut Shema and colleagues found that boosting the amount of PKMzeta could potentially help one recall memories that were on the brink of being forgotten. In testing, lowering the levels of PKMzeta caused rats to lose track of memories more quickly, but the zany part is that boosting levels on a specific day helped animals recall memories from days prior -- days where they weren't having PKMzeta jacked into their system. Heaven help our legal system should this ever get FDA approval for use in humans.
Zelrix electronic anti-migraine patch heads to the FDA for review
We've seen some electronic devices that promise to cure migraines in the past, but NuPathe's Zelrix patch certainly seems to be among the most practical, and it's just gotten one step closer to the US market. The company recently announced that the FDA has accepted its filing for a New Drug Application, and it says it now has a target date of August 29, 2011 for the FDA to complete its review. As for the patch itself, it's a single-use patch that relies on a mild electrical current to "actively transport" the anti-migraine drug sumatriptan through the skin using a process called iontophoresis. That, NuPathe says, not only allows for a more consistent and controlled delivery of the drug, but it also circumvents the nausea and vomiting that can occur when taking the medication orally -- which the company notes can be enough to cause some folks to avoid taking the medication altogether. Head on past the break for the complete press release.
NC State gurus find 'Goldilocks' of DNA self-assembly, look to improve drug-delivery vehicles
We're guessing that most Wolfpackers in the greater Raleigh area are in full-on tailgate mode right now, but aside from laying a beating on the Seminoles this evening, NC State faithful are also trumpeting a new DNA discovery that could one day make it easy to get vital drugs to hard-to-reach places within you. Researchers from the university have purportedly discovered the 'Goldilocks' of DNA self-assembly, which holds promise for technologies ranging from drug delivery to molecular sensors. The concept, known as DNA-assisted self-assembly, has been vastly improved by using "computer simulations of DNA strands to identify the optimal length of a DNA strand for self-assembly." You see, perfection occurs when strands aren't long enough to intertwine with each other, yet not short enough to simply fold over on each other. We know, it's a lot to wrap your brain around with half a hot dog shoved in your mouth, but hit the video after the break for a... shall we say, more visual explanation.
